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Leopoldstadt 2. Wieden 1. Margareten 2. Working in a holiday region: biotech in the Tyrol Tyrol is known throughout the world as an excellent place for a holiday.

The research performed in the fields of cell engineering, implant and implantation technology, medical device, health and bioinformatics, bioanalytics and drug delivery enjoys international renown.

Tyrolean life-science companies benefit from academic know-how. For example, the AlcaSynn Pharmaceuticals company develops opioid receptor blockers for use in pain therapy.

Thiomatrix utilizes thiolated polymer systems for mucosal delivery of biomolecules such as polypeptides, and Innovacell works on new cell-therapy processes to replace damaged muscle tissue.

The health informatics company Icoserve designed an advanced image-management software solution for hospitals. Over the past few years, about 50, square metres of lab and office space have been provided by public authorities.

Part of this organisation is the Competence Centre Medicine Tirol, where researchers and entrepreneurs are currently collaborating on a total of 19 projects.

Healthcare technology in Styria: medical devices, white biotechnology and regenerative medicine In Styria, the biotech scene is small but very dynamic.

ProtAffin, a KarlFranzens University spin-off, develops genetically modified proteins for treating inflammatory illnesses. Transgenic animal models employed in the study of neurodegenerative diseases is the speciality of JSW Research, also based in Graz.

White biotechnology and upscaling technologies are rapidly growing in Styria. Total healthcare solutions, including testing facilities, are made available at the Center For Medical Research, where their partners perform clinical trials phases The enormous potential of the network results from its unique density of competence.

Political Commitments human. Currently, we cooperate with Austrian institutions and companies as well as institutions in the South-Eastern markets and with selected international partners.

Welcoming business environment, high quality of life and a prime location in the heart of Europe contribute to leveraging growth in the region.

Together with universities, research institutes and the big players on site they form a thriving Life Science community. Extensive know-how and potential among companies and research bodies Upper Austria is the leading federal province with regard to commerce, industry and exports.

Moreover, the role of biosciences and biotechnology in Upper Austria is to be massively enlarged. Expansion in the education and research areas Education and research are of fundamental importance.

Close integration of business into the Life Sciences strategy For Upper Austria, four areas of application are of major significance.

The predominant factor in this regard is medical technology, which is to be the object of expansion. Almost companies are active in this economic segment.

The competent further development of foods technology is an important factor in international competition. Keywords: functional food, proteins, lactose, enzymes, etc.

Around enterprises are involved in this rapidly expanding, internationally oriented sector.

Biotechnology is supplying impulses for production innovations such as filter membranes in wastewater and waste treatment.

Interesting areas of application in the Life Sciences field include process technology in the chemicals and pharmaceuticals sectors, as well as in the paper industry.

Positive preconditions for commerce and industry. Companies planning to enter this sector find an excellent framework provided by the Health and Foods Clusters and the Environmental Technology Network.

Companies are assisted in their activities and on the path to new technologies and international markets. In summary, it can be stated that the Life Sciences sector is booming, the preconditions are positive and an entry into the area will pay off.

Technopol Krems The city of Krems is pursuing an emphasis on biomedicine tissue engineering, cellular therapies, extracorporeal blood purification and healthcare services.

And the best evidence that they are the right directions is the host of international businesses striving for Krems.

Technopol Tulln The Technopol Tulln focuses intensively on research and development in the fields of agro- and environmental biotechnology.

Biotechnical processes are developed in the areas of plant and animal production, as well as environmental protection.

More than highly specialized researchers are already active on-site. The Research Institute for Agro-Biotechnology IFA Tulln , a Department of the University of Natural Resources and Applied Life Sciences in Vienna, ranks among the leading research institutes in Europe in the fields of biotechnology in animal and plant-production, bioanalytics, environmental biotechnology and technology of natural materials.

Harald Gohm T. Nevertheless, when we speak of Tirol as a business location, there is one thing we should not forget: apart from tourism, Tirol has developed into a specialised high-tech location.

Tirol as a business location - mountainous habitat, healthy business The Tirolean economy has a small structure.

Thousands of small and medium-sized companies operate in the various areas of the production, trade and service industries.

The balanced representation of industry guarantees healthy economic growth. Tirol leads the way in Austria with 1. The gross value added in Tirol was approximately Next to small and medium-sized companies, the larger domestic companies are also responsible for this.

These larger companies impress worlwide with their know-how and high level of quality. The Tyrolean Life Science Research fields of cell engineering, implant- and implantation technology, medical device, health- and bioinformatics, bioanalytics and drug delivery are internationally established.

The first industrially manufactured Penicillin was made in the small village of Kundl. Ideal transport connections make Tirol a hub for the international exchange of goods and knowledge.

Tirolean Fortitude Along with the exceptional position of its location, Tirol offers an economic area with further advantages for companies and employees.

Three universities, two colleges of higher education and also technical schools ensure an excellent standard of education. Professional customer-orientated administration and politicians who act as direct contacts for economic matters guarantee flexible and uncomplicated bureaucratic procedures.

In combination with the high standard of living, these are noticable advantages for a location. The combination of qualified jobs and optimal leisure time possibilities, embedded in unique natural surroundings, attract top international executives to Tirol.

Are you interested in further information? Agneter has dealt with preclinical and clinical expert reports for marketing authorization of medicinal products.

Agneter was appointed Medical and Marketing Director of an international pharmaceutical company in Austria. As pricing and reimbursement questions are gaining importance and complexity, Agneter PharmaConsulting provides a full service in working out strategies and preparing reimbursement dossiers.

Agneter is working with several pharmaceutical companies. In Agneter PharmaConsulting was founded with the scopes of clinical expert reports, drug evaluation, pricing and reimbursement and strategic advice on clinical trails.

We focus on the development and manufacture of microbial derived biopharmaceuticals, such as proteins, plasmid DNA, antibody fragments and protein scaffolds.

In state-of-the-art GMP facilities we manufacture products for clinical trials and market supply. Boehringer-Gasse A Vienna T.

Also in , we received the Customer Value Award for providing our international clients with the highest quality customer manufacturing.

Value through Innovation. Products are highly purified in modern recovery and purification units. Columns up to 1.

Explosion-proof areas allow steps requiring the use of organic solvents or large scale high performance liquid chromatography.

Located on the campus of the University of Veterinary Medicine Vienna and having its roots in the Institute of Bacteriology, Mycology and Hygiene, a university institute which is internationally recognised for its research on mycoplasmas, Mycosafe is well-positioned to become a mycoplasma testing service center and developer of new mycoplasma testing assays of the future.

Since December , Mycosafe is operating under the new name Mycosafe Diagnostics GmbH and is today considered as a leading contract service and research organisation which plays an important role in the success of its clients in research and biopharmaceutical production by assuring the mycoplasma biosafety of cell banks, in-process samples, lot-release samples and raw materials.

Mycosafe also offers PhEur and US FDA compliant validation studies to qualify each mycoplasma testing assay for the respective product to be tested.

In addition, Mycosafe offers its expertise in mycoplasma species identification and strain characterisation using molecular techniques, and also provides consultancy and training services in the area of mycoplasmology.

In cooperation with academic and industrial partners, Mycosafe is developing and validating new innovative DNA-based testing systems for the detection and identification of mycoplasmas.

Both of these substances are approved as human drugs and are commonly used in hospitals. The drug is easy to use and the therapeutic dose has no significant side effects.

To the present day 16 countries have participated in the UACI research with more than scientists in 46 universities and research institutes.

The results of UACI research are regularly presented on international congresses and published in scientific magazines. Reading about that, one wonders if this discovery is suppressed because it is against some pharmaceutical companies' interests.

Our products target segments characterised by both unmet medical need and interesting revenue potential. This encompasses developmental skills, regulatory procedures and the synthesis of complex APIs and forms the key to a range of longterm competitive advantages.

The majority of our revenues are already generated through product sales. We consciously avoid broad-based and cost-intensive exploratory research.

Extensive in-house skills and resources are supplemented by numerous top-level scientific co-operations with contract research organisations, institutes and universities.

Profitable contract manufacturing orders, API synthesis and imaging diagnostic sales all contribute to steady revenue flows.

Additional potential lies in pipeline developments of new drugs for attractive segments of the pharmaceutical market. This in turn allows us to offer partners a wide range of services in the fields of contract synthesis and manufacturing.

We use our experience and knowledge to help clients to set up a mycotoxin control system and to manage the risk.

Romer Labs Diagnostic GmbH www. However, the purity of mycotoxin standards is often uncertain. Founded in the year , Biopure has developed world-leadership in the production of highly purified mycotoxin calibrants.

Today thousands of labs in all continents benefit from the liquid and solid calibrants supplied from Biopure. Because of new regulations, the testing of mycotoxins has become very important also for remote places, where no Labs can be established.

Vitateq was the first to discover that afamin, a human serum transport protein for vitamin E, is a major player in the development of reproductive tract tumors, infertility and neurodegenerative diseases.

Presently, there are no comparable products available on the market. Afamin exerts neuroprotective properties in neuronal cell culture models.

These results indicate a high potential for diagnostic and therapeutic applications of afamin not only in the fields of fertility and cancer, but also neuroprotection.

Vitateq has established an ELISA kit for quantifying afamin in human serum as a novel diagnostic tool for early, improved and more specific detection of cancers occurring in human reproductive tissues.

This ELISA kit is fully developed and has already been tested successfully in several human patient groups. Vitateq Biotechnology is a spin-off company from the Medical University of Innsbruck with international management.

Our product development is protected by several international patents. Our new diagnostic test will be based on a variety of significant and biologically relevant biomarkers.

Biochemistry Core competence of the company is to study changes of gene expression and function in human tissues during cancer development and ageing, with the intention to identify and validate new targets for early diagnosis of tumour-, age- and environmentinduced diseases.

The products are currently in preclinical trials. At present, cervical cancer screening is the largest existing screening market in oncology.

Worldwide, there are Human papilloma virus HPV induced cervical cancer is the most common cancer beneath breast cancer in women and, if detected early, cervical cancer is a fully preventable disease!

Partnerships Amynon Biotech GmbH follows an efficient strategy to protect intellectual property and has filed several patents. The rights for production and distribution are licensed to partners from the pharmaceutical industry.

As a science-based and market oriented company Amynon is permanently interested in international cooperations with diagnostic and pharmaceutical companies to further develop and commercialize Amynon's products.

Make it visible - HPV-E7 oncoprotein detection in cervical smear. Its objective is to develop novel and innovative drugs for the treatment of diseases with a high degree of unmet medical needs.

Presently no drug is available to treat this life-threatening condition that is caused by a variety of diseases such as sepsis and pneumonias due to viral infections e.

ARDS may be the key complication in the context of the feared pandemic outbreak of a new influenza virus. A second project of Apeiron relates to the biologic role of Cbl-b, a key check-point molecule of the immune system.

The enzyme Cbl-b has been recognized as critical negative regulator of autoimmunity. Modulation of Cbl-b activity may enable effective vaccination strategies against weakly immunogenic antigens such as cancer, malaria, HIV-infection, or alternatively may lead to novel therapies for autoimmune diseases.

In a strategic partnership Apeiron identifies and profiles substances that interfere with Cbl-b activity. In a third project, Apeiron in a strategic alliance identifies compounds that modulate the biologic action of DREAM, a key molecule for the natural pain regulation by controlling the expression of an endogenous opioid.

Such compounds are expected to be powerful analgesics, based on the induction of the production of an endogenous opioid.

Most of them have trusted CIS repeatedly with various kind of projects, from early development to submission for Marketing Authorisation.

CIS offers consulting and project management services, starting from the switch preclinical-to clinical development up to submission for marketing authorisation.

CIS has a broad experience in conducting audits in all major areas of clinical research. CIS prepares companies for inspections by health authorities.

The EUCODIS proprietary approach extends these natural limitations to recombination of highly diverged sequences and thus creates proteins with novel properties coded by the recombined gene sequence.

In addition to these collaborative service agreements, internal projects are focussed on biopharmaceuticals anti-inflammation and bone metabolism and two important enzyme classes.

Iterative stimulation of a human B-cell line allows the generation of specific, human antibodies or novel biopharmaceuticals.

EUCODIS has a strong international network of leading experts for its individual projects which ensure optimal project design and performance of research and collaborative projects.

Major research collaborations with the Necker Faculty of Medicine and leading institutes in Europe linked via a major grant from EU focussing on human antibodies are in place.

Concurrently with the foundation of the U. The company aims to become a leader in the development and commercialisation of pharmaceuticals targeting fundamental mechanisms of inflammationbased tissue injury.

Inflammation-based tissue injury is well known as a major component in the pathogenesis of important diseases, such as myocardial infarction, septic and hemorrhagic shock, graft rejection or rheumatoid arthritis.

In parallel, research programs for additional indications for FX06 will be conducted and suitable indications for clinical development will be identified, with an emphasis on septic shock.

New peptides already identified will be analysed with respect to their usefulness for autoimmune diseases. In parallel, partnering discussions with a pharmaceutical partner for performance of phase III trials and commercialization will be started.

Phase IIa trials for additional indications for FX06 will be initiated in FIBREX Medical currently concentrates its efforts on the preclinical and clinical development of the products currently in its pipeline.

However, in-licensing of product candidates late preclinical or early clinical with a strategic fit will actively be pursued to complement the pipeline.

High quality PTR-MS instruments for satisfied customers from industry, university and private research have been employed in the food and fermentation control industries as well as for process and environmental monitoring.

The very low detection limit for volatile organic compounds VOCs , realtime measurements due to fast response times, and continuous monitoring capabilities are the major advantages of our innovative PTR-MS system.

This leads to our unique low detection threshold for trace compounds in the range of a few pptv. Compared to ordinary gas chromotography, our PTR-MS system provides the possibility of online and real-time measurement, because the instrument's response time is less than ms.

The company is also dedicated to providing top-level clinical research on a broader range of illnesses throughout all stages of therapy development.

JSW-Research uses modern molecular biology techniques and has also designed a variety of disease relevant cell and animal models for characterizing drug effects.

Interlacing modular systems facilitate step-by-step analysis of candidate substances from basic in vitro to complex in vivo assays, complemented by a full range of histological, biochemical and behavioral evaluation methods.

JSW-Research generates high quality research on two levels: First the company performs highly standardised contract research for the pharmaceutical industry and for well renown institutions like Harvard University, Mayo Clincs and the University of Tel Aviv.

Academia represents a significant proportion of the customers, since the Austrian enterprise is one of the technology leaders regarding preclinical and clinical research.

In a second branch JSW-Research performs proprietary drug development programs. The Austrian contract research and drug development company JSW-Research has specialised on the performance of experimental and clinical studies in the field of neurodegenerative diseases.

Windisch, CEO of JSW-Research: For the identification and evaluation of compounds we apply a broad spectrum of biochemical, cell biological and molecular biological methods.

Furthermore we are specialists in neuroscience and behavior and work with various animal models including transgenic mice. Windisch founded the company in and gained profound knowledge during a 20 year career in drug research.

The clinical department of JSWResearch offers services in all clinical phases and indications. Innovative research projects with high development and marketing chances are financed and managed by the Kompetenzzentrum Medizin Tirol KMT.

The main areas of research are implant technology, bioanalytics, cell therapy and nano- bio technology. With regard to project management, KMT has specialist experience and expertise in project planning, together with developing and managing project proposals, particularly in the area of life sciences.

As part of the contribution to the European research agenda, KMT is extending its customer services and promoting development of the Life Science Cluster Tirol at an international level.

KMT, as a center of excellence, has well established contacts with key stakeholders industry, academic, public authorities in life sciences in the region and beyond.

The first results from research and development activities of some KMT projects have already been successfully introduced onto the market.

The Tyrol region in Austria is particularly strong in the areas of cell therapy, immunology and bioanalytics. KMT manages large research and co-operative programmes on a national and international level.

Since its foundation in the year , Lambda GmbH has responded to the challenges in this field and now specializes in a wide range of molecular biological methods of detection.

The innovative biotechnology company with its roots in Freistadt, Austria, develops and produces biochips as ready to use kits for applications in research and routine diagnostics.

DNA analysis and customer research work are carried out by experienced specialists in Lambda's own laboratories. Through its close collaboration with associates in industry and research, Lambda assures the practicality and reliability of its solutions.

Thus, the company which is owned by the Greiner Bio-One GmbH, develops biochips for the medical diagnostics. Products consist of complete test systems with all the necessary buffers and solutions.

The on-chip quality-control system, for which Lambda has already applied for a patent, guarantees perfect monitoring of every stage of analysis and production and therefore virtually excludes false negative and false positive results.

An IVD-compatible microarray scanner together with an integrated analysis software permit the fully automatic high-throughput detection and analysis of up to four biochips at once.

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